Using high-throughput methods

In the last week or so, I caught this note from the process development team at BI who use automation to screen cation exchange resins for conditions that led to significant improvements in their main isoform.  I love the experimental layout

One of these days, I've got to set up a 96-well plate with multiple resins.  The options are just too fun to consider.  In this example, I would have proposed a different design.  For example, a central composite design with 8 centerpoints completed in replicate would use up all 32-wells.  Recognizing that the pH is the harder variable to change, then JMP include this to generate a design that is easily programmed.  The result would be data with significant statistical power and improved predictive ability for scale-up.